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[Abstract:]

#1

Science / Oral Insulin

Last post by Recusant - Today at 03:31:46 AM

This really looks promising. Will probably be expensive at first, once it's approved.

"Nanotech opens door to future of insulin medication" | Phys.org

An international team, led by researchers from Australia, have developed a system using nanotechnology that could allow people with diabetes to take oral insulin in the future. The researchers say the new insulin could be eaten by taking a tablet or even embedded within a piece of chocolate.

The new nano carrier, tested in mice, rats and baboon animal models, could help people with diabetes avoid side-effects linked to insulin injections such as hypoglycemia (a low blood sugar event, when too much insulin has been injected).

These animal studies have shown that the greatest strength of the nano-scale material is that it can react to the body's blood sugar levels. The coating dissolves and releases the insulin when there is a high concentration of blood sugar and importantly does not release the insulin in low blood sugar environments.

The new oral insulin uses a type of nano-scale material that is 1/10,000th the width of a human hair. The material acts similarly to acid resistant coating on tablets, which protects it from being destroyed by stomach acid. But this new coating instead surrounds individual insulin molecules and becomes a "nano carrier"—acting like a courier to ferry insulin molecules in the body to the places it needs to act.

[Continues . . .]

The paper is open access--

"Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia" | Nature Nanotechnology

Abstract:

Injectable insulin is an extensively used medication with potential life-threatening hypoglycaemic events. Here we report on insulin-conjugated silver sulfide quantum dots coated with a chitosan/glucose polymer to produce a responsive oral insulin nanoformulation.

This formulation is pH responsive, is insoluble in acidic environments and shows increased absorption in human duodenum explants and Caenorhabditis elegans at neutral pH. The formulation is sensitive to glucosidase enzymes to trigger insulin release.

It is found that the formulation distributes to the liver in mice and rats after oral administration and promotes a dose-dependent reduction in blood glucose without promoting hypoglycaemia or weight gain in diabetic rodents. Non-diabetic baboons also show a dose-dependent reduction in blood glucose. No biochemical or haematological toxicity or adverse events were observed in mice, rats and non-human primates. The formulation demonstrates the potential to orally control blood glucose without hypoglycaemic episodes.

#2

Laid Back Lounge / Re: What's on your mind today?

Last post by hermes2015 - Today at 03:25:07 AM

Mazel tov!

#3

Laid Back Lounge / Re: What's on your mind today?

Last post by Recusant - Today at 03:20:07 AM

Well done ! 

#4

Laid Back Lounge / Re: What's on your mind today?

Last post by Dark Lightning - Today at 01:54:03 AM

Nice!

#5

Laid Back Lounge / Re: What's on your mind today?

Last post by Tank - Today at 01:43:18 AM

My son, top right, celebrates with Lando Norris at his first F1 win in Miami 2024!

#6

History / Re: What's this?

Last post by Dark Lightning - May 05, 2024, 07:06:34 PM

It is an aid for knitting fingers for gloves.

#7

History / Re: What's this?

Last post by zorkan - May 05, 2024, 05:42:34 PM

Is it possible: https://phil.cdc.gov/Details.aspx?pid=23312

#8

History / What's this?

Last post by zorkan - May 05, 2024, 05:41:09 PM

https://www.popsci.com/science/ancient-mystery-object/

#9

Laid Back Lounge / Re: animals in your life

Last post by billy rubin - May 05, 2024, 04:05:42 PM

actuall its doing pretty well. these geese are quite acclimated to people, and this is a reasonably quiet alley. later when the hoslings are walking it might be problematic. theres no water nearby.

#10

Laid Back Lounge / Re: Game: The Next Person... (...

Last post by billy rubin - May 05, 2024, 04:03:47 PM

false

posession of opium and opium smoking utensils. long long ago and far away

the next person hss never had a kitchen full of rats