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Legalize It

Started by Recusant, January 18, 2020, 08:56:00 PM

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Dark Lightning

I was not clear, last post. The OD stuff would be from drugs other than MJ, like cocaine or something. I have experience from the '70s with MJ, and maybe used it 7 to 10 times.

Magdalena

#16
Quote from: Recusant on May 03, 2021, 08:48:10 AMThe creeps in Washington DC are making noises about putting a federal limit on potency. They haven't legalized it fer fuck's sake. You're going to put regulations on something you don't allow people to legally possess? Sounds like a non-starter to me, but then I don't have a politician's ability to get their cranium firmly inserted into their nether orifice. Bastards. I've never thought much of Feinstein, from her rise to power in San Francisco (taking over for the murdered Mayor Moscone) and on through her notably successful career.  :sulk:

"The cannabis industry's next war: How strong should its weed be?" | Politico

QuoteProposals to limit the potency of THC have been introduced by both Democrats and Republicans, and are likely to proliferate as the legal pot market expands and matures. Lawmakers in Congress have also expressed concern about the increasing potency of weed. In March, the co-chairs of the Senate Caucus on International Narcotics Control — Dianne Feinstein (D-Calif.) and John Cornyn (R-Texas) — argued that federal agencies should consider recommending THC caps.

[Link to full article.]

Forty-five years ago --

Hmmm
Maybe they should watch this video right before their meetings... :notsure:

"I've had several "spiritual" or numinous experiences over the years, but never felt that they were the product of anything but the workings of my own mind in reaction to the universe." ~Recusant

Randy

I've never tried marijuana. Now that I'm terminally ill (for those who just joined I have cancer) and my oncologist has yet to prescribe it. It wouldn't matter though as the stuff I'm on is a lot stronger and right now I just don't want to feel pain. In my case marijuana won't be enough.

I think it should be legalized and under FDA scrutiny. I wouldn't mind going to la la land to escape this life for a while.

The only reason I'm up now is the pain. I took a few pills (different types) and it's tapering it off. If my doctor prescribed marijuana I'd pick it up and do as the doctor has instructed
"Maybe it's just a bunch of stuff that happens." -- Homer Simpson
"Some people focus on the destination. Atheists focus on the journey." -- Barry Goldberg

billy rubin

marijuana never helped me with pain. it just messed me up so much i forgot about it for a while

but the pain was preferable to the marijuana


set the function, not the mechanism.

Magdalena

Marijuana has helped me with body aches, stomach discomfort, mood, appetite, etc.
You just have to know when too much will "mess you up" instead of help you.
In my case, the Marijuana was preferable to the pain.
-I'm just saying.  :reading:

"I've had several "spiritual" or numinous experiences over the years, but never felt that they were the product of anything but the workings of my own mind in reaction to the universe." ~Recusant

billy rubin

even asmall amount messes me up, magdalena. i have no physiological tolerance. the stuff to me is super unpleasant.

its always been that way 


set the function, not the mechanism.

Magdalena

Quote from: billy rubin on May 12, 2021, 10:30:35 AM
even asmall amount messes me up, magdalena. i have no physiological tolerance. the stuff to me is super unpleasant.

its always been that way
That's too bad.  :therethere:

"I've had several "spiritual" or numinous experiences over the years, but never felt that they were the product of anything but the workings of my own mind in reaction to the universe." ~Recusant

billy rubin

nah

i get drug tested now all the time anyway because i have a class a license. couldn't smoke it if i wanted to

when i quit driving i'll just start growing poppies


set the function, not the mechanism.

Recusant

"Cannabis Treatment Can Reduce Kids' Epileptic Seizures by 86%, Early Results Show" | Science Alert

QuoteThe anti-seizure qualities of the cannabis plant can likely not be boiled down to a single compound, like cannabidiol (CBD), according to emerging research.

Studies in Australia have recently revealed numerous other compounds in the cannabis plant that also show anticonvulsant effects. Some of them could even be more powerful than CBD.

A small observational study in the United Kingdom now backs up those findings. When 10 children with intractable forms of epilepsy began using a medicine that contained the whole cannabis plant, including cannabidiols, terpenes, and flavonoids, their seizure frequency fell by an average of 86 percent.

The research was not randomized or placebo-controlled, however, these case studies show far greater success than the outcomes of CBD extracts alone.

[Continues . . .]

The paper is open access:

"Medical cannabis for severe treatment resistant epilepsy in children: a case-series of 10 patients" | BMJ Paediatrics Open

QuoteAbstract:

Objectives To report the findings of a case-series of 10 children suffering with intractable epilepsies in the UK to determine the feasibility for using whole-plant cannabis medicines to treat seizures in children.

Setting This study was conducted retrospectively through collecting clinical data from caretakers and clinicians on study outcome variables. Participants were recruited through the MedCann Support and End our Pain charity groups which are patient representative groups that support children who are using medical cannabis to treat their epilepsies. Medicines were prescribed to patients by clinicians in both National Health Service and private medical practices. Follow-up calls were conducted throughout the period January 2021 to May 2021 to keep data recorded up to date.

Participants Ten children, 18 years old or under, with intractable epilepsies were recruited from two charities. There were no limitations on diagnosis, sex or ethnic origin.

Interventions Participants were treated with a range of whole-plant medical cannabis oils. Individual dosing regimens were determined by clinicians.

Primary outcome measure The primary outcome measure was seizure frequency.

Results Seizure frequency across all 10 participants reduced by 86% with no significant adverse events. Participants reduced use of antiepileptic drugs from an average of seven to one following treatment with medical cannabis. We also noted significant financial costs of £874 per month to obtain these medicines through private prescriptions.

Conclusions This study establishes the feasibility of whole-plant medical cannabis as an effective and well-tolerated medicine for reducing seizure frequency in children suffering with intractable epilepsies. These findings justify the potential value of further research into the reported therapeutic benefit of whole-plant medicinal cannabis products.
"Religion is fundamentally opposed to everything I hold in veneration — courage, clear thinking, honesty, fairness, and above all, love of the truth."
— H. L. Mencken


Tank

Good research by the look of it.
If religions were TV channels atheism is turning the TV off.
"Religion is a culture of faith; science is a culture of doubt." ― Richard P. Feynman
'It is said that your life flashes before your eyes just before you die. That is true, it's called Life.' - Terry Pratchett
Remember, your inability to grasp science is not a valid argument against it.

Recusant

#25
May be good news for some vipers out there. :far out:

"Cannabis Revealed to Have Anti-Aging Effect in The Brains of Mice" | Science Alert

QuoteTetrahydrocannabinol (THC), the main active ingredient in cannabis, has been shown to reverse conventional signs of brain aging in mice – a discovery that could help in finding ways to keep our brains healthier and sharper for longer as we get older.

The new study builds on what was already known about the endocannabinoid system and the cannabinoid receptor type-1 (CB1) in the brain, and their links to the gradual cognitive decline that comes with age.

What's more, the team from Germany and Israel was able to observe how the anti-aging effects were taking place: through a signalling pathway involving the mTOR protein, which is associated with the healthy regulation of cell metabolism, and from there the metabolome (the overall composition of small molecules in the body).

"We have now been able to show that treatment with THC has a tissue-dependent and dual effect on mTOR signaling and the metabolome," says molecular biologist Andras Bilkei-Gorzo from the University of Bonn in Germany.

Some of the same researchers had previously found that low doses of cannabis could improve memory and learning capabilities in aging mice, suggesting that there might be a relationship between THC and cognition worth exploring.

[Continues . . .]

The paper is open access:

"Bidirectional Effect of Long-Term Δ9-Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome" | ACS Pharmacology & Translational Science

QuoteAbstract:

Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of rapamycin (mTOR) has a major impact on aging by regulating cellular metabolism. Although reduced mTOR signaling has a general antiaging effect, it can negatively affect the aging brain by reducing synaptogenesis and thus cognitive functions. Increased mTOR activity facilitates aging and is responsible for the amnestic effect of the cannabinoid receptor 1 agonist Δ9-tetrahydrocannabinol (THC) in higher doses.

Long-term low-dose Δ9-THC had an antiaging effect on the brain by restoring cognitive abilities and synapse densities in old mice. Whether changes in mTOR signaling and metabolome are associated with its positive effects on the aging brain is an open question. Here, we show that Δ9-THC treatment has a tissue-dependent and dual effect on mTOR signaling and the metabolome.

In the brain, Δ9-THC treatment induced a transient increase in mTOR activity and in the levels of amino acids and metabolites involved in energy production, followed by an increased synthesis of synaptic proteins. Unexpectedly, we found a similar reduction in the mTOR activity in adipose tissue and in the level of amino acids and carbohydrate metabolites in blood plasma as in animals on a low-calorie diet.

Thus, long-term Δ9-THC treatment first increases the level of energy and synaptic protein production in the brain, followed by a reduction in mTOR activity and metabolic processes in the periphery. Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective antiaging and pro-cognitive medication.
"Religion is fundamentally opposed to everything I hold in veneration — courage, clear thinking, honesty, fairness, and above all, love of the truth."
— H. L. Mencken


Tank

If religions were TV channels atheism is turning the TV off.
"Religion is a culture of faith; science is a culture of doubt." ― Richard P. Feynman
'It is said that your life flashes before your eyes just before you die. That is true, it's called Life.' - Terry Pratchett
Remember, your inability to grasp science is not a valid argument against it.