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Started by Claireliontamer, July 12, 2017, 08:18:49 PM
Quote from: xSilverPhinx on August 30, 2021, 04:31:42 PMQuote from: Dark Lightning on August 27, 2021, 05:36:42 PM Googly eyes on the brain? Where's Silver!? I'm here, trying to catch up! I saw that article about the mini-brain with Googly eyes a few days ago, and I thought the exact same thing!
Quote from: Dark Lightning on August 27, 2021, 05:36:42 PM Googly eyes on the brain? Where's Silver!?
QuoteFor the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer's disease and found that it develops in a very different way than previously thought. Their results could have important implications for the development of potential treatments.The international team, led by the University of Cambridge, found that instead of starting from a single point in the brain and initiating a chain reaction which leads to the death of brain cells, Alzheimer's disease reaches different regions of the brain early. How quickly the disease kills cells in these regions, through the production of toxic protein clusters, limits how quickly the disease progresses overall.The researchers used post-mortem brain samples from Alzheimer's patients, as well as PET scans from living patients, who ranged from those with mild cognitive impairment to those with full-blown Alzheimer's disease, to track the aggregation of tau, one of two key proteins implicated in the condition.[Continues . . .]
QuoteAbstract:Both the replication of protein aggregates and their spreading throughout the brain are implicated in the progression of Alzheimer's disease (AD). However, the rates of these processes are unknown and the identity of the rate-determining process in humans has therefore remained elusive. By bringing together chemical kinetics with measurements of tau seeds and aggregates across brain regions, we can quantify their replication rate in human brains. Notably, we obtain comparable rates in several different datasets, with five different methods of tau quantification, from postmortem seed amplification assays to tau PET studies in living individuals. Our results suggest that from Braak stage III onward, local replication, rather than spreading between brain regions, is the main process controlling the overall rate of accumulation of tau in neocortical regions. The number of seeds doubles only every ∼5 years. Thus, limiting local replication likely constitutes the most promising strategy to control tau accumulation during AD.[¶ added. - R]
QuoteA man paralyzed from the neck down due to a spinal cord injury he sustained in 2007 has shown he can communicate his thoughts, thanks to a brain implant system that translates his imagined handwriting into actual text.The device – part of a longstanding research collaboration called BrainGate – is a brain-computer interface (BCI), that uses artificial intelligence (AI) to interpret signals of neural activity generated during handwriting.In this case, the man – called T5 in the study, and who was 65 years of age at the time of the research – wasn't doing any actual writing, as his hand, along with all his limbs, had been paralyzed for several years.But during the experiment, reported in Nature earlier in the year, the man concentrated as if he were writing – effectively, thinking about making the letters with an imaginary pen and paper.[Continues . . .]
QuoteAbstract:Brain–computer interfaces (BCIs) can restore communication to people who have lost the ability to move or speak. So far, a major focus of BCI research has been on restoring gross motor skills, such as reaching and grasping or point-and-click typing with a computer cursor. However, rapid sequences of highly dexterous behaviours, such as handwriting or touch typing, might enable faster rates of communication. Here we developed an intracortical BCI that decodes attempted handwriting movements from neural activity in the motor cortex and translates it to text in real time, using a recurrent neural network decoding approach. With this BCI, our study participant, whose hand was paralysed from spinal cord injury, achieved typing speeds of 90 characters per minute with 94.1% raw accuracy online, and greater than 99% accuracy offline with a general-purpose autocorrect. To our knowledge, these typing speeds exceed those reported for any other BCI, and are comparable to typical smartphone typing speeds of individuals in the age group of our participant (115 characters per minute). Finally, theoretical considerations explain why temporally complex movements, such as handwriting, may be fundamentally easier to decode than point-to-point movements. Our results open a new approach for BCIs and demonstrate the feasibility of accurately decoding rapid, dexterous movements years after paralysis.[¶ added. - R]
QuoteChronic rhinosinusitis, which causes a persistent blocked nose and headaches among other symptoms, affects 11 percent of people in the US – and new research has found a link between the condition and changes in brain activity.The team behind the study is hoping that the link will help explain some of the other common effects of the persistent inflammation: finding it hard to focus, struggling with bouts of depression, having trouble sleeping, and dizziness.Finding a connection between the underlying disease and the neural processing happening elsewhere could be vital in understanding the chronic condition, along with efforts to find better and more effective ways to treat it.[. . .]Although this new research doesn't show that chronic sinus inflammation directly causes changes in brain activity, the association is strong enough to make it worthy of further investigation: future studies could look at how this brain activity changed after treatment for those diagnosed with chronic rhinosinusitis, for example.For now, the researchers say that medical professionals should be more mindful of the mental health symptoms that go along with diseases like the sinus inflammation one studied here – and how they might be playing out in the rest of the body.[Continues . . .]
QuoteKey pointsQuestion Is sinonasal inflammation associated with functional brain connectivity?Findings In this case-control study of 22 patients with chronic rhinosinusitis and 22 healthy controls, participants with sinonasal inflammation showed decreased brain connectivity within the frontoparietal network, a major functional hub. This region also showed increased connectivity to areas that activate during introspective processing and decreased connectivity to areas that are involved in detection and response to stimuli.Meaning This study provides initial evidence for alterations in functional brain connectivity as a potential basis for cognitive dysfunction seen in patients with chronic rhinosinusitis.
QuoteAir pollution doesn't just impact the health of your lungs and heart. Recent research has found fine particulate matter can also cause damage to the brain, and scientists think they've finally figured out how.In mouse models, it appears that ultra-fine particles in the air can enter the lungs, seep into the bloodstream, and ultimately invade the brain.Once the toxins are present in neurological tissue, they are much harder for the immune system to clear. In fact, the authors found airborne particles were retained in the brain for longer than any other organ in the mouse body.It's not yet clear if the same pathways exist in humans, but the findings suggest that if particles are small enough, they can slip past the blood brain barrier – a check point that usually stops dangerous solutes and other harmful components in blood from reaching the central nervous system.A leaky blood brain barrier has been linked to cognitive damage before, but the current study is one of the first to show air pollutants sneaking by the brain's border patrol.[Continues . . .]
Quote from: Icarus on June 25, 2022, 03:35:04 AMMeasuring instruments were aimed at the screen printing and sifting industry. The tools measured the tension in a membrane. It was also useful to measure the tension in aircraft fabric and a few other things like audio speaker diaphragms, I also made meters to measure the relative hardness of elastomers, including racing tires. Those were designed mainly to measure the Shore A hardness of screen printing squeegees.